反应详情

温度

110 °C

(S)-tert-butyl 2-methylpiperazine-1-carboxylate (1 g, 4.99 mmol), 4-fluorobenzonitrile (0.605 g, 4.99 mmol), and K2CO3 (0.897 g, 6.49 mmol) were combined into a vial equipped with a stir bar. The reaction was heated to 110° C. for 48 h. Cooled to RT, diluted with EA and filtered. Concentrated to a clear oil and purified on silica gel (80 g, 10-20% EA in Hex) to give a clear oil (450 mg, 30% yield) which became a crystalline solid upon sitting. [M+H] calc'd for C17H23N3O2, 301; found, 301.

1. customa vial equipped with a stir bar
2. temperatureCooled to RT
3. filtrationfiltered
4. concentrationConcentrated to a clear oil
5. custompurified on silica gel (80 g, 10-20% EA in Hex)