反应详情

2,4-pentanedione (205.4 ml, 2.0 mol), acetone (100 ml), n-butyl bromide (54 ml, 0.5 mol), and potassium carbonate (34.55 g, 0.25 mol) were fed into a reaction vessel, air in the vessel was replaced with nitrogen, and reflux was carried out for 48 hours. The resultant solid was filtered out, and the solvent was distilled off by means of an evaporator. After that, unreacted 2,4-pentanedione was distilled off under reduced pressure by means of a diaphragm. Then, the remainder was distilled in a vacuum to yield 3-n-butyl 2,4-pentanedione (43.25 g, 55% yield).

1. temperaturereflux
2. filtrationThe resultant solid was filtered out
3. distillationthe solvent was distilled off by means of an evaporator
4. distillationAfter that, unreacted 2,4-pentanedione was distilled off under reduced pressure by means of a diaphragm
5. distillationThen, the remainder was distilled in a vacuum