HCID 178451294, compound → HCID 178429101, compound

HRID 2078333Notes

Reaction equation

HRID 2078333 reaction equation
[OH:1][C:2]1[C:3]([CH3:34])([CH3:33])[C:4]2[C:9]([C:10](=[O:23])[C:11]=1[C:12]([NH:14][CH2:15][C:16]([O:18]C(C)(C)C)=[O:17])=[O:13])=[CH:8][CH:7]=[C:6]([NH:24][CH2:25][CH2:26][N:27]1[CH2:32][CH2:31][O:30][CH2:29][CH2:28]1)[CH:5]=2>C(O)(C(F)(F)F)=O>[OH:1][C:2]1[C:3]([CH3:34])([CH3:33])[C:4]2[C:9]([C:10](=[O:23])[C:11]=1[C:12]([NH:14][CH2:15][C:16]([OH:18])=[O:17])=[O:13])=[CH:8][CH:7]=[C:6]([NH:24][CH2:25][CH2:26][N:27]1[CH2:32][CH2:31][O:30][CH2:29][CH2:28]1)[CH:5]=2

Participants

3

Reactant 1

HCID 178451294HCID 178451294, compound

Product 1

HCID 178429101HCID 178429101, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

Tert-butyl 2-(2-hydroxy-1,1-dimethyl-7-(2-morpholinoethylamino)-4-oxo-1,4-dihydronaphthalene-3-carboxamido)acetate (25 mg, 53 μmol) was dissolved in TFA (2 mL) at room temperature for 30 minutes and concentrated to give crude product. The crude product was purified via preparatory TLC to give the title compound. MS (ESI) m/z: Calculated; 417.5: Observed; 418.1.

Workup

  1. concentrationconcentrated
  2. customto give crude product
  3. customThe crude product was purified via preparatory TLC

Sources & evidence

ORD record
ord-fbf8f2c708fc4edaa686f0ae471307ca
Source dataset
uspto-grants-2011_04
Patent number
US07928139B2

Reaction notes

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