反应详情

To a solution of compound 25 (300 mg, 0.92 mmol) in water (2 mL) and methanol (4 mL) was added potassium carbonate (509 mg, 3.7 mmol) and the resulting reaction mixture was allowed to stir at reflux for 2 hours. The reaction mixture was poured onto 3N HCl and extracted with dichloromethane (3×20 mL). The combined dichloromethane extracts were dried over anhydrous sodium sulfate and concentrated in vacuo to provide 110 mg of 26 as a white solid (272 mg theoretical, 40% yield).

1. customthe resulting reaction mixture
2. temperatureat reflux for 2 hours
3. extractionextracted with dichloromethane (3×20 mL)
4. dry with materialThe combined dichloromethane extracts were dried over anhydrous sodium sulfate
5. concentrationconcentrated in vacuo