Hydrochloric Acid → HCID 86634854, compound

HRID 2079009Notes

Reaction equation

HRID 2079009 reaction equation
C[O:2][C:3]([C:5]1[CH:6]=[CH:7][C:8]2[O:17][CH2:16][CH2:15][C:14]3[CH:13]=[C:12](C(=O)N(C4C=CC(Cl)=CC=4Cl)C)[S:11][C:10]=3[C:9]=2[CH:30]=1)=[O:4].[OH-].[Na+].Cl>C1COCC1.C(O)C>[S:11]1[C:10]2[C:9]3[CH:30]=[C:5]([C:3]([OH:4])=[O:2])[CH:6]=[CH:7][C:8]=3[O:17][CH2:16][CH2:15][C:14]=2[CH:13]=[CH:12]1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 866348552-[(2,4-Dichloro-phenyl)-methyl-carbamoyl]-4,5-dihydro-6-oxa-1-thia-benzo[e]azulene-9-carboxylic acid methyl ester

Product 1

HCID 86634854HCID 86634854, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 2-[(2,4-dichloro-phenyl)-methyl-carbamoyl]-4,5-dihydro-6-oxa-1-thia-benzo[e]azulene-9-carboxylic acid methyl ester (700 mg) in THF (8 mL) and ethanol (4 mL) was added sodium hydroxide solution (121 mg in 4 mL of water) and the reaction stirred at room temperature for 16 h. The reaction was then acidified with 2 M hydrochloric acid and the resulting solid was filtered and air-dried to give 2-(2,4-dichloro-phenyl)-methyl-carbamoyl]-4,5-dihydro-6-oxa-1-thia-benzo[e]azulene-9-carboxylic acid.

Workup

  1. filtrationthe resulting solid was filtered
  2. customair-dried

Sources & evidence

ORD record
ord-3528ff9abcfd4a98b009232eae07b0f9
Source dataset
uspto-grants-2011_04
Patent number
US07928248B2

Reaction notes

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