Tetrahydrofuran → Methyl 2-[4-(4-fluorophenoxy)benzenesulfonyl]-6-(2-morpholin-4-ylethoxy)-1,2,3,4-tetrahydroisoquinoline-1-carboxylate

HRID 207944Notes

Reaction equation

HRID 207944 reaction equation
[CH2:73]1[O:74][CH2:75][CH2:76][CH2:77]1.[F:20][c:21]1[cH:22][cH:23][c:24]([O:25][c:26]2[cH:27][cH:28][c:29]([S:32](=[O:33])(=[O:34])[N:35]3[CH:36]([C:46](=[O:47])[O:48][CH3:49])[c:37]4[cH:38][cH:39][c:40]([OH:45])[cH:41][c:42]4[CH2:43][CH2:44]3)[cH:30][cH:31]2)[cH:50][cH:51]1.[O:52]1[CH2:53][CH2:54][N:55]([CH2:58][CH2:59][OH:60])[CH2:56][CH2:57]1.[O:61]=[C:62]([O:63][CH2:64][CH3:65])[N:66]=[N:67][C:68]([O:69][CH2:70][CH3:71])=[O:72].[c:1]1([P:2]([c:3]2[cH:4][cH:5][cH:6][cH:7][cH:8]2)[c:9]2[cH:10][cH:11][cH:12][cH:13][cH:14]2)[cH:15][cH:16][cH:17][cH:18][cH:19]1>>[F:20][c:21]1[cH:22][cH:23][c:24]([O:25][c:26]2[cH:27][cH:28][c:29]([S:32](=[O:33])(=[O:34])[N:35]3[CH:36]([C:46](=[O:47])[O:48][CH3:49])[c:37]4[cH:38][cH:39][c:40]([O:45][CH2:59][CH2:58][N:55]5[CH2:54][CH2:53][O:52][CH2:57][CH2:56]5)[cH:41][c:42]4[CH2:43][CH2:44]3)[cH:30][cH:31]2)[cH:50][cH:51]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 11776TriphenylphosphineHCID 611632-MorpholinoethanolHCID 220568ethyl N-ethoxycarbonyliminocarbamateHCID 68679822Methyl 2-[4-(4-fluorophenoxy)benzenesulfonyl]-6-hydroxy-1,2,3,4-tetrahydro-isoquinoline-1-carboxylate

Product 1

HCID 68680877Methyl 2-[4-(4-fluorophenoxy)benzenesulfonyl]-6-(2-morpholin-4-ylethoxy)-1,2,3,4-tetrahydroisoquinoline-1-carboxylate

Sources & evidence

ORD record
ord-37baa490021941b497f15eb606e97b70
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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