Hydrochloric Acid → HCID 67103768, compound

HRID 2079564Notes

Reaction equation

HRID 2079564 reaction equation
[Br:1][C:2]1[CH:7]=[C:6]([CH3:8])[C:5]([N:9]2[C:13]3[N:14]=[C:15]([CH3:27])[N:16]=[C:17]([N:18]4[CH2:23][CH2:22][CH:21]([CH2:24][CH2:25][OH:26])[CH2:20][CH2:19]4)[C:12]=3[C:11]([CH3:28])=[CH:10]2)=[C:4]([CH3:29])[CH:3]=1.[ClH:30]>C(O)C.C(OCC)(=O)C>[ClH:30].[Br:1][C:2]1[CH:7]=[C:6]([CH3:8])[C:5]([N:9]2[C:13]3[N:14]=[C:15]([CH3:27])[N:16]=[C:17]([N:18]4[CH2:23][CH2:22][CH:21]([CH2:24][CH2:25][OH:26])[CH2:20][CH2:19]4)[C:12]=3[C:11]([CH3:28])=[CH:10]2)=[C:4]([CH3:29])[CH:3]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 10389386HCID 10389386, compound

Product 1

HCID 67103768HCID 67103768, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

To a suspension of 2-{1-[7-(4-bromo-2,6-dimethyl-phenyl)-2,5-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-piperidin-4-yl}-ethanol (6.41 g) in ethanol (51 mL) was added 4 M HCl in ethyl acetate (4.2 mL) under ice-cooling. After removing the solvent, ethyl acetate (26 mL) was added to the residue. The mixture was stirred overnight to afford a white crystal. The crystal was collected by filtration to give the title compound (6.1 g).

Workup

  1. temperaturecooling
  2. customAfter removing the solvent, ethyl acetate (26 mL)
  3. additionwas added to the residue
  4. customto afford a white crystal
  5. filtrationThe crystal was collected by filtration

Sources & evidence

ORD record
ord-f860ea377590453dafca8e72e05d946d
Source dataset
uspto-grants-2011_04
Patent number
US07932259B2

Reaction notes

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