Urea → HCID 178517417, compound

HRID 2079640Notes

Reaction equation

HRID 2079640 reaction equation
[NH2:1][C:2]1[CH:9]=[C:8]([Br:10])[CH:7]=[CH:6][C:3]=1[CH:4]=O.[NH2:11][C:12](N)=[O:13]>O>[Br:10][C:8]1[CH:9]=[C:2]2[C:3]([CH:4]=[N:11][C:12]([OH:13])=[N:1]2)=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 1176UreaHCID 179145982-Amino-4-bromobenzaldehyde

Product 1

HCID 178517417HCID 178517417, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
180 °C

Procedure

A mixture of 2-amino-4-bromobenzaldehyde (1 eq) and urea (14 eq) was heated to 180° C. in an oil bath under Argon for 1 h. Water was added to after cooling to ambient temperature. The solid was collected by filtration and air dried to give product in 95% yield. ES/MS m/z 225/227 (MH+).

Workup

  1. temperatureto after cooling to ambient temperature
  2. filtrationThe solid was collected by filtration and air
  3. customdried
  4. customto give product in 95% yield

Sources & evidence

ORD record
ord-1f41e7f7cd014e8f942972d3dde3615b
Source dataset
uspto-grants-2011_04
Patent number
US07932262B2

Reaction notes

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