反应详情

To a solution of ethyl 2-[6-(naphthalene-2-sulfonylamino)-3-aza-bicyclo[3.1.0]hex-3-yl]-pyrimidine-5-carboxylate (0.182 g, 0.47 mmol) in DCM (10 ml) was added triphenylphosphine (0.26 g, 1 mmol) and 1-(2-hydroxyethyl)-2-methylimidazole (0.084 mg, 0.75 mmol). Diisopropylazodicarboxylate (0.167 ml, 0.85 mmol) was then added and the solution stirred overnight. The mixture was loaded directly onto a silica gel column and purified eluting with 2% MeOH/DCM to give the title compound (0.242 g, 90%). 1H NMR (300 MHz, CDCl3) δ: 1.36 (3H, t), 1.60-1.80 (3H, m), 2.57 (3H, s), 3.43 (2H, t), 3.48-3.62 (2H, m), 3.70 (2H, d), 4.35 (2H, t), 4.33 (2H, q), 6.90 (1H, d), 6.98 (1H, d), 7.60-7.80 (2H, m) 7.82 (1H, dd), 7.95 (1H, dd), 8.02 (2H, d), 8.43 (1H, s), 8.72 (2H, s).

1. custompurified
2. washeluting with 2% MeOH/DCM