Hydrochloric Acid → HCID 66876317, compound

HRID 2079806Notes

Reaction equation

HRID 2079806 reaction equation
[ClH:1].C(OC([NH:9][CH:10]1[CH2:13][N:12]([C:14]2[N:19]=[CH:18][C:17]([C:20]([O:22][CH2:23][CH3:24])=[O:21])=[CH:16][N:15]=2)[CH2:11]1)=O)(C)(C)C>O1CCOCC1>[ClH:1].[NH2:9][CH:10]1[CH2:11][N:12]([C:14]2[N:19]=[CH:18][C:17]([C:20]([O:22][CH2:23][CH3:24])=[O:21])=[CH:16][N:15]=2)[CH2:13]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66876489HCID 66876489, compound

Product 1

HCID 66876317HCID 66876317, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

4M HCl in dioxane (15 ml) was added to ethyl 2-{3-[(tert-butoxycarbonyl)amino]azetidin-1-yl}pyrimidine-5-carboxylate (323 mg, 1 mmol) and the reaction stirred at r.t. for 30 min. The suspension was concentrated in vacuo to give the title compound as a white solid (323 mg, quant.). LCMS purity 78%, m/z 223 [M+H]+.

Workup

  1. concentrationThe suspension was concentrated in vacuo

Sources & evidence

ORD record
ord-fc42fa6d31ae4a1daba87a895bc64fbc
Source dataset
uspto-grants-2011_04
Patent number
US07932246B2

Reaction notes

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