Potassium Carbonate → HCID 86628682, compound

HRID 2079902Notes

Reaction equation

HRID 2079902 reaction equation
C(=O)([O-])[O-].[K+].[K+].[CH:7]([N:10]1[C:18]2[C:13](=[CH:14][CH:15]=[C:16]([NH:19][S:20]([CH3:23])(=[O:22])=[O:21])[CH:17]=2)[C:12]([C:24]2[CH:29]=[CH:28][C:27]([C:30]#[C:31][Si](C)(C)C)=[CH:26][N:25]=2)=[CH:11]1)([CH3:9])[CH3:8]>CO>[CH:7]([N:10]1[C:18]2[C:13](=[CH:14][CH:15]=[C:16]([NH:19][S:20]([CH3:23])(=[O:22])=[O:21])[CH:17]=2)[C:12]([C:24]2[CH:29]=[CH:28][C:27]([C:30]#[CH:31])=[CH:26][N:25]=2)=[CH:11]1)([CH3:9])[CH3:8]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 57442259HCID 57442259, compound

Product 1

HCID 86628682HCID 86628682, compoundYield 27%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Add potassium carbonate (208 mg, 1.5 mmol) to N-[1-isopropyl-3-(5-trimethylsilanylethynyl-pyridin-2-yl)-1H-indol-6-yl]-methanesulfonamide (63 mg, 0.15 mmol) in MeOH (5 mL) and stir at room temperature for an hour. Evaporate the solvent. Purification of the crude residue using silica gel chromatography gave 14 mg (27% yield) of the desired product.

Workup

  1. customEvaporate the solvent
  2. customPurification of the crude residue

Sources & evidence

ORD record
ord-7e266e9c87424fa1902f9320769b4635
Source dataset
uspto-grants-2011_04
Patent number
US07932284B2

Reaction notes

Loading…