反应详情

温度

160 °C

To a solution of 2,6dibromopyridine (20 g, 84.4 mmol) and phenol (7.94 g, 84.4 mmol) in dimethylsulfoxide (200 mL) was added potassium tert-butoxide (9.47 g, 84.4 mmol), and the solution was stirred at 160° C. for 7 hours. The reaction solution was allowed to room temperature, ethyl acetate and water were added for partitioning, the organic layer was washed with water and dried over anhydrous magnesium sulfate. The solvent was evaporated, the residue was purified by silica gel column chromatography (hexane:ethyl acetate=10:1), and 2-bromo-6-phenoxy-pyridine (19.6, 93%) was obtained as a yellow solid.

1. customwas allowed to room temperature
2. customfor partitioning
3. washthe organic layer was washed with water
4. dry with materialdried over anhydrous magnesium sulfate
5. customThe solvent was evaporated
6. customthe residue was purified by silica gel column chromatography (hexane:ethyl acetate=10:1)