Methanol → HCID 58387985, compound

HRID 2080144Notes

Reaction equation

HRID 2080144 reaction equation
C[O:2][C:3]([C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][CH:14]=1)[N:11]=[CH:10][C:9]([Br:15])=[CH:8]2)=[O:4].O1CCCC1.CO.O.[OH-].[Li+:25]>O>[Li+:25].[Br:15][C:9]1[CH:10]=[N:11][C:12]2[C:7]([CH:8]=1)=[CH:6][C:5]([C:3]([O-:4])=[O:2])=[CH:14][CH:13]=2

Participants

6

Reactant 4

HCID 887MethanolHCID 8028TetrahydrofuranHCID 168937Lithium hydroxide, monohydrateHCID 566361246-Quinolinecarboxylic acid, 3-bromo-, methyl ester

Product 1

HCID 58387985HCID 58387985, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a mixture of 3-bromo-quinoline-6-carboxylic acid methyl ester described in Preparation Example 162 (26 mg, 0.098 mmol) and tetrahydrofuran (2 mL) were added methanol (0.2 mL), lithium hydroxide monohydrate (4.1 mg, 0.098 mmol) and water (0.2 mL), and the solution was stirred overnight at room temperature. The solvent was evaporated in vacuo, and the title compound (27 mg) was obtained.

Workup

  1. customThe solvent was evaporated in vacuo

Sources & evidence

ORD record
ord-69828af9848b4de789c5f318648cb106
Source dataset
uspto-grants-2011_04
Patent number
US07932272B2

Reaction notes

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