HCID 67101411, compound → HCID 67100937, compound

HRID 2080651Notes

Reaction equation

HRID 2080651 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([CH:7]=[CH:8][C:9]2[C:10]([O:29][CH3:30])=[CH:11][C:12]([O:27][CH3:28])=[C:13]([C:15]3[N:19]([C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=4[Cl:26])[N:18]=[CH:17][CH:16]=3)[CH:14]=2)=[CH:3][CH:2]=1>[Pt].CCOCC>[N:1]1[CH:2]=[CH:3][C:4]([CH2:7][CH2:8][C:9]2[C:10]([O:29][CH3:30])=[CH:11][C:12]([O:27][CH3:28])=[C:13]([C:15]3[N:19]([C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=4[Cl:26])[N:18]=[CH:17][CH:16]=3)[CH:14]=2)=[CH:5][CH:6]=1

Participants

4

Reactant 1

HCID 67101411HCID 67101411, compound

Product 1

HCID 67100937HCID 67100937, compound

Reagents, catalysts & solvents 2

HCID 23939PlatinumCatalystHCID 3283Diethyl EtherSolvent

Procedure

11.C.2 Hydrogenation of “E7” using 5% Pt/C as catalyst gives the compound 5-{5-[2-(pyridin-4-yl)ethyl]2,4-dimethoxyphenyl}-1-(2-chlorophenyl)-1H-pyrazole and ether cleavage thereof gives the compound 5-{5-[2-(pyridin-4-yl)ethyl]2,4-dihydroxyphenyl}-1-(2-chlorophenyl)-1H-pyrazole, retention time [min] 1.397, M+H+[m/e] 392.86.

Sources & evidence

ORD record
ord-f50e82fc5e7f456bbeed7eef274caadc
Source dataset
uspto-grants-2011_04
Patent number
US07932401B2

Reaction notes

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