反应详情

温度

90 °C

100 mg of ethyl 5-fluoropyridine-2-carboxylate obtained from Reference Example 18 (step 2) was dissolved in 1 ml of dimethylformamide and 1 ml of methanol, and 163 mg of potassium carbonate was added to it and stirred under heat at 90° C. for 40 minutes. This was neutralized with aqueous 10% citric acid solution, extracted with chloroform, and the organic layer was washed with saturated saline water. After dried, the solvent was evaporated away under reduced pressure, and the residue was purified through silica gel column chromatography (developing solvent: hexane/ethyl acetate) to obtain 46.5 mg of methyl 5-methoxypyridine-2-carboxylate as a white crystal.

1. extractionextracted with chloroform
2. washthe organic layer was washed with saturated saline water
3. customAfter dried
4. customthe solvent was evaporated away under reduced pressure
5. customthe residue was purified through silica gel column chromatography (developing solvent: hexane/ethyl acetate)