反应详情

The compound (436 mg) obtained in Example 11-9 was dissolved in THF (21.8 ml) and added with lithium aluminum hydride (138.7 mg) and the whole was stirred at room temperature for 24 hours. The reaction solution was added with ethyl acetate, methanol, and a 10% aqueous potassium sodium tartrate solution, and the whole was stirred for 1 hour, followed by extraction with chloroform. The extract was washed with a saturated saline solution and then dried with anhydrous sodium sulfate, followed by concentration under reduced pressure. The residue was purified through silica gel column chromatography (chloroform/ethyl acetate), thereby obtaining the subject compound (189.7 mg) as a yellow oily substance.

1. extractionfollowed by extraction with chloroform
2. washThe extract was washed with a saturated saline solution
3. dry with materialdried with anhydrous sodium sulfate
4. concentrationfollowed by concentration under reduced pressure
5. customThe residue was purified through silica gel column chromatography (chloroform/ethyl acetate)