反应详情

The compound (189 mg) obtained in Example 11-10 was dissolved in DMF (5.6 ml) and added with potassium carbonate (108.5 mg) and carbethoxyphthalimide (172.0 mg) and the whole was stirred at room temperature for 3 hours. The reaction solution was added with water and subjected to extraction with chloroform. The extract was dried with anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified through silica gel column chromatography (chloroform/methanol), thereby obtaining the subject compound (253 mg) as a yellow oily substance.

1. extractionsubjected to extraction with chloroform
2. dry with materialThe extract was dried with anhydrous sodium sulfate
3. concentrationconcentrated under reduced pressure
4. customThe residue was purified through silica gel column chromatography (chloroform/methanol)