Diethylamine → HCID 67103497, compound

HRID 2080751Notes

Reaction equation

HRID 2080751 reaction equation
[CH3:1][O:2][C:3](=[O:47])[C:4]1[CH:13]=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][C:5]=1[NH:14][C:15](=[O:46])[CH:16]([NH:28]C(OCC1C2C=CC=CC=2C2C1=CC=CC=2)=O)[CH2:17][CH2:18][CH2:19][NH:20][C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22].C(NCC)C>CN(C=O)C>[CH3:1][O:2][C:3](=[O:47])[C:4]1[CH:13]=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][C:5]=1[NH:14][C:15](=[O:46])[CH:16]([NH2:28])[CH2:17][CH2:18][CH2:19][NH:20][C:21]([O:23][C:24]([CH3:27])([CH3:25])[CH3:26])=[O:22]

Participants

4

Reactant 2

HCID 8021DiethylamineHCID 67103715HCID 67103715, compound

Product 1

HCID 67103497HCID 67103497, compoundYield 125.8%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The compound (236.0 mg) obtained in Example 14-1 was dissolved in anhydrous DMF (4.7 ml) and added with diethylamine (4.7 ml) and the whole was stirred at room temperature for 1 hour. After completion of the reaction, the solvent was distilled off under reduced pressure. The residue was purified through silica gel column chromatography (chloroform/methanol), thereby obtaining the subject compound (194.7 mg) as a colorless viscous solid.

Workup

  1. customAfter completion of the reaction
  2. distillationthe solvent was distilled off under reduced pressure
  3. customThe residue was purified through silica gel column chromatography (chloroform/methanol)

Sources & evidence

ORD record
ord-eb5afd67057944c9a852eb33e0b5bc6f
Source dataset
uspto-grants-2011_04
Patent number
US07932281B2

Reaction notes

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