Water → HCID 67103576, compound

HRID 2080752Notes

Reaction equation

HRID 2080752 reaction equation
C[O:2][C:3](=O)[C:4]1[CH:13]=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][C:5]=1[NH:14][C:15](=[O:29])[CH:16]([NH2:28])[CH2:17][CH2:18][CH2:19][NH:20][C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22].[CH3:31]C(C)([O-])C.[Na+].O>C1COCC1>[CH2:11]([O:10][C:8]([C:7]1[CH:12]=[CH:13][C:4]2[C:3](=[O:2])[NH:28][CH:16]([CH2:17][CH2:18][CH2:19][NH:20][C:21]([O:23][C:24]([CH3:26])([CH3:25])[CH3:27])=[O:22])[C:15](=[O:29])[NH:14][C:5]=2[CH:6]=1)=[O:9])[CH3:31]

Participants

5

Reactant 3

HCID 962WaterHCID 23676156Sodium t-butoxideHCID 67103497HCID 67103497, compound

Product 1

HCID 67103576HCID 67103576, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
60 °C

Procedure

The compound (303.8 mg) obtained in Example 14-2 and sodium t-butoxide (manufactured by Wako Pure Chemical Industries, Ltd.) (138.4 mg) were dissolved in anhydrous THF (6.0 ml) and the whole was stirred at 60° C. for 15 hours. After completion of the reaction, water was added thereto and the whole was subjected to extraction with chloroform.

Workup

  1. additionwas added
  2. extractionthe whole was subjected to extraction with chloroform

Sources & evidence

ORD record
ord-0134a6f5c53349bb88b84bf692e670dd
Source dataset
uspto-grants-2011_04
Patent number
US07932281B2

Reaction notes

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