反应详情

温度

60 °C

The compound (152.5 mg) obtained in Example 24-1 was dissolved in anhydrous DMF (6.1 ml) and added with cesium carbonate (299.0 mg) and 4-bromomethyl-benzonitrile (manufactured by Tokyo Kasei Kogyo Co., Ltd.) (184.0 mg). The whole was stirred overnight at 60° C. and then stirred at 80° C. for additional 24 hours. After completion of the reaction, the solvent was distilled off. The resultant was added with water, subjected to extraction with chloroform, and dried with magnesium sulfate. The solvent was distilled off. The residue was purified through silica gel column chromatography (hexane/ethyl acetate), thereby obtaining the subject compound (88.8 mg) as a colorless oily substance.

1. stirringstirred at 80° C. for additional 24 hours
2. customAfter completion of the reaction
3. distillationthe solvent was distilled off
4. additionThe resultant was added with water
5. extractionsubjected to extraction with chloroform
6. dry with materialdried with magnesium sulfate
7. distillationThe solvent was distilled off
8. customThe residue was purified through silica gel column chromatography (hexane/ethyl acetate)