反应详情

The compound (613 mg) obtained in Example 29-4 was dissolved in THF (18 ml) and added with 60% sodium hydride (105 mg). After that, the whole was gradually added with methyl iodide (373 mg) and stirred at room temperature for 16 hours. After completion of the reaction, the solvent was distilled off under reduced pressure. The residue was dissolved in chloroform, washed with water, and subjected to extraction with chloroform. The organic layer was washed with a saturated saline solution and dried with anhydrous sodium sulfate. After filtration, the solvent was distilled off. The residue was purified through silica gel column chromatography (hexane/ethyl acetate), thereby obtaining the subject compound (160 mg) as a brown solid.

1. customAfter completion of the reaction
2. distillationthe solvent was distilled off under reduced pressure
3. dissolutionThe residue was dissolved in chloroform
4. washwashed with water
5. extractionsubjected to extraction with chloroform
6. washThe organic layer was washed with a saturated saline solution
7. dry with materialdried with anhydrous sodium sulfate
8. filtrationAfter filtration
9. distillationthe solvent was distilled off
10. customThe residue was purified through silica gel column chromatography (hexane/ethyl acetate)