Hydrochloric Acid → HCID 11671482, compound

HRID 2080877Notes

Reaction equation

HRID 2080877 reaction equation
C([O:3][C:4](=[O:46])[CH2:5][N:6]1[CH:10]=[CH:9][N:8]=[C:7]1[CH2:11][N:12]([CH2:25][C:26]1[CH:31]=[CH:30][C:29]([CH2:32][N:33]([CH2:35][CH2:36][CH2:37][CH2:38][N:39]([CH2:43][CH2:44][CH3:45])[CH2:40][CH2:41][CH3:42])[CH3:34])=[CH:28][CH:27]=1)[CH2:13][C:14]1[N:15]([CH2:19][C:20]([O:22]CC)=[O:21])[CH:16]=[CH:17][N:18]=1)C.Cl>O1CCOCC1>[C:4]([CH2:5][N:6]1[CH:10]=[CH:9][N:8]=[C:7]1[CH2:11][N:12]([CH2:13][C:14]1[N:15]([CH2:19][C:20]([OH:22])=[O:21])[CH:16]=[CH:17][N:18]=1)[CH2:25][C:26]1[CH:27]=[CH:28][C:29]([CH2:32][N:33]([CH2:35][CH2:36][CH2:37][CH2:38][N:39]([CH2:40][CH2:41][CH3:42])[CH2:43][CH2:44][CH3:45])[CH3:34])=[CH:30][CH:31]=1)([OH:46])=[O:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67103359HCID 67103359, compound

Product 1

HCID 11671482HCID 11671482, compoundYield 139.5%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
100 °C

Procedure

The compound (34.1 mg) obtained in Example 86-1 was dissolved in dioxane (1.0 ml) and added with concentrated hydrochloric acid (500 μl) at room temperature and the whole was stirred at an outside temperature of 100° C. for 4 hours. After completion of the reaction, the resultant was concentrated and evaporated to dryness under reduced pressure, thereby obtaining a hydrochloride (43.4 mg) of the subject compound as a white solid.

Workup

  1. customAfter completion of the reaction
  2. concentrationthe resultant was concentrated
  3. customevaporated to dryness under reduced pressure

Sources & evidence

ORD record
ord-272dc6c51cf14ef98d95ed857e0b11da
Source dataset
uspto-grants-2011_04
Patent number
US07932281B2

Reaction notes

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