Hydrochloric Acid → HCID 23155566, compound

HRID 2080880Notes

Reaction equation

HRID 2080880 reaction equation
C[O:2][C:3](=[O:24])[C:4]1[CH:9]=[CH:8][C:7]([CH2:10][N:11]([CH2:13][CH2:14][CH2:15][CH2:16][N:17]([CH2:21][CH2:22][CH3:23])[CH2:18][CH2:19][CH3:20])[CH3:12])=[CH:6][CH:5]=1.[OH-].[Na+].Cl>CO>[CH2:21]([N:17]([CH2:18][CH2:19][CH3:20])[CH2:16][CH2:15][CH2:14][CH2:13][N:11]([CH2:10][C:7]1[CH:6]=[CH:5][C:4]([C:3]([OH:24])=[O:2])=[CH:9][CH:8]=1)[CH3:12])[CH2:22][CH3:23]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 23155527HCID 23155527, compound

Product 1

HCID 23155566HCID 23155566, compoundYield 91%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The compound (234 mg) obtained in Example 88-2 was dissolved in methanol (2.5 ml) and added with 1 mol/l sodium hydroxide aqueous solution (2.5 ml) and the whole was stirred at room temperature for 16 hours. After completion of the reaction, the solution was neutralized with a 1 mol/l hydrochloric acid and the solvent was distilled off under reduced pressure. The residue was suspended in ethanol and then a white precipitate was filtrated out. The organic layer was distilled off under reduced pressure and the residue was dried under vacuum, thereby obtaining the subject compound (204 mg) as a pale-yellow oily substance.

Workup

  1. customAfter completion of the reaction
  2. distillationthe solvent was distilled off under reduced pressure
  3. filtrationa white precipitate was filtrated out
  4. distillationThe organic layer was distilled off under reduced pressure
  5. customthe residue was dried under vacuum

Sources & evidence

ORD record
ord-24e4bc596e9e43d9ba04032f2bbf932a
Source dataset
uspto-grants-2011_04
Patent number
US07932281B2

Reaction notes

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