Diethylamine → HCID 86614920, compound

HRID 2080894Notes

Reaction equation

HRID 2080894 reaction equation
[CH2:1]([O:3][C:4](=[O:35])[C@H:5]([NH:17]C(OCC1C2C=CC=CC=2C2C1=CC=CC=2)=O)[CH2:6][CH2:7][CH2:8][NH:9][C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[CH3:2].C(NCC)C>CN(C=O)C>[CH2:1]([O:3][C:4](=[O:35])[C@H:5]([NH2:17])[CH2:6][CH2:7][CH2:8][NH:9][C:10]([O:12][C:13]([CH3:15])([CH3:14])[CH3:16])=[O:11])[CH3:2]

Participants

4

Reactant 2

HCID 8021DiethylamineHCID 67103783HCID 67103783, compound

Product 1

HCID 86614920HCID 86614920, compoundYield 114.1%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The compound (1.9846 g) obtained in Example 96-1 was dissolved in DMF (19 ml) and added with diethylamine (14 ml) and the whole was stirred at room temperature for 30 minutes. After completion of the reaction, the solvent was distilled off. The residue was purified through silica gel column chromatography (chloroform/methanol), thereby obtaining the subject compound (1.2212 g) as a colorless oily substance.

Workup

  1. customAfter completion of the reaction
  2. distillationthe solvent was distilled off
  3. customThe residue was purified through silica gel column chromatography (chloroform/methanol)

Sources & evidence

ORD record
ord-ac75322babd2480d9dd16a284b29588a
Source dataset
uspto-grants-2011_04
Patent number
US07932281B2

Reaction notes

Loading…