HCID 11664000, compound → HCID 11577273, compound

HRID 2080895Notes

Reaction equation

HRID 2080895 reaction equation
C([O:3][C:4](=[O:40])[C@H:5]([N:16]([CH2:18][C:19]1[CH:24]=[CH:23][C:22]([CH2:25][N:26]([CH2:34][C:35]2[NH:36][CH:37]=[CH:38][N:39]=2)[CH2:27][C:28]2[N:29]([CH3:33])[CH:30]=[CH:31][N:32]=2)=[CH:21][CH:20]=1)[CH3:17])[CH2:6][CH2:7][CH2:8][N:9]([CH2:13][CH2:14][CH3:15])[CH2:10][CH2:11][CH3:12])C>Cl.O>[CH2:13]([N:9]([CH2:10][CH2:11][CH3:12])[CH2:8][CH2:7][CH2:6][C@@H:5]([N:16]([CH2:18][C:19]1[CH:24]=[CH:23][C:22]([CH2:25][N:26]([CH2:34][C:35]2[NH:36][CH:37]=[CH:38][N:39]=2)[CH2:27][C:28]2[N:29]([CH3:33])[CH:30]=[CH:31][N:32]=2)=[CH:21][CH:20]=1)[CH3:17])[C:4]([OH:40])=[O:3])[CH2:14][CH3:15]

Participants

4

Reactant 1

HCID 11664000HCID 11664000, compound

Product 1

HCID 11577273HCID 11577273, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolvent2×HCID 962WaterSolvent

Procedure

The hydrochloride (200 mg) of the compound obtained in EXAMPLE 96-4 was dissolved in concentrated hydrochloric acid (3 ml) and water (0.2 ml), and the whole was refluxed under heating for 4 hours. After completion of the reaction, the solvent was distilled off, thereby obtaining a hydrochloride (175.1 mg) of the subject compound as a white solid.

Workup

  1. temperatureunder heating for 4 hours
  2. customAfter completion of the reaction
  3. distillationthe solvent was distilled off

Sources & evidence

ORD record
ord-40fbcd08864943169b43d9a47847a98f
Source dataset
uspto-grants-2011_04
Patent number
US07932281B2

Reaction notes

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