反应详情

温度

85 °C

A mixture of 4-chlorobenzoyl chloride (0.92 mL, 7.22 mmol) (Aldrich), 3-hydroxy-4-methyl-benzoic acid hydrazide (1.0 g, 6.02 mmol) (from Example 6 supra) and triethylamine (1.36 mL) in tetrahydrofuran (20 mL) was heated at 85° C. for 1 day. The reaction mixture was partitioned between ethyl acetate and water. The precipitate washed with ethyl acetate and dichloromethane and dried to give 3-hydroxy-4-methyl-benzoic acid N′-(4-chloro-benzoyl)-hydrazide. (Yield 1.28 g, 70%).

1. customThe reaction mixture was partitioned between ethyl acetate and water
2. washThe precipitate washed with ethyl acetate and dichloromethane
3. customdried