Hydrochloric Acid → HCID 70047317, compound

HRID 2081226Notes

Reaction equation

HRID 2081226 reaction equation
[F:1][C:2]1[C:10]2[N:9]([CH3:11])[C:8]3[CH2:12][CH2:13][N:14]([CH2:17][C:18]4[N:19]=[CH:20][NH:21][C:22]=4[CH3:23])[C:15](=[O:16])[C:7]=3[C:6]=2[CH:5]=[CH:4][CH:3]=1.[ClH:24]>CO>[ClH:24].[F:1][C:2]1[C:10]2[N:9]([CH3:11])[C:8]3[CH2:12][CH2:13][N:14]([CH2:17][C:18]4[N:19]=[CH:20][NH:21][C:22]=4[CH3:23])[C:15](=[O:16])[C:7]=3[C:6]=2[CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 172999Lurosetron

Product 1

HCID 70047317HCID 70047317, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 6-fluoro-2,3,4,5-tetrahydro-5-methyl-2-[(5-methyl-1H-imidazol-4-yl) methyl]-1H-pyrido[4,3-b]indol-1-one (260 mg) in methanol (10 ml) was treated with ethereal hydrogen chloride and the mixture was then concentrated in vacuo. The residue was triturated with ether (15 ml) to give the title compound (230 mg) as a solid, m.p. 275°-278°.

Workup

  1. concentrationthe mixture was then concentrated in vacuo
  2. customThe residue was triturated with ether (15 ml)

Sources & evidence

ORD record
ord-2497383a90b54518a6ee12b6479af9a5
Source dataset
uspto-grants-1993_02
Patent number
US05183820

Reaction notes

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