Cyclopentanone → HCID 59347806, compound

HRID 20814Notes

Reaction equation

HRID 20814 reaction equation
Cl.[CH3:2][O:3][CH2:4][CH2:5][NH:6][CH3:7].C1(=O)CCCC1.[C-]#N.[K+].CN(C)[C:19]1([C:24]#[N:25])[CH2:23][CH2:22][CH2:21][CH2:20]1>O>[CH3:7][N:6]([CH2:5][CH2:4][O:3][CH3:2])[C:19]1([C:24]#[N:25])[CH2:23][CH2:22][CH2:21][CH2:20]1

Participants

6

Reactant 4

HCID 8452CyclopentanoneHCID 9032Potassium CyanideHCID 107730491-(Dimethylamino)cyclopentanecarbonitrileHCID 18670924(2-Methoxyethyl)(methyl)amine hydrochloride

Product 1

HCID 59347806HCID 59347806, compoundYield 82%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The title compound (3.39 g; 82%) was prepared from N-(2-methoxyethyl)methylamine hydrochloride (2.84 g; 22.6 mmol), cyclopentanone (1.90 g, 22.6 mmol) and potassium cyanide (1.47 g; 22.6 mmol) in water (15 ml) in a similar manner to that described in D1. 1H NMR (CDCl3) δ: 1.83 (6H, m). 2.20 (2H, m), 2.48 (3H, s), 2.68 (2H, t), 3.46 (3H, s), 3.5 (2H, t).

Sources & evidence

ORD record
ord-e3b63cb316884a4c9f6038e4082ef5cd
Source dataset
uspto-grants-2010_06
Patent number
US07745642B2

Reaction notes

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