Acetone → HCID 15052152, compound

HRID 2081491Notes

Reaction equation

HRID 2081491 reaction equation
[N:1]12[CH2:8]CC([CH2:5][CH2:6]1)[CH2:3][CH:2]2O.[C:10]1([CH3:21])[CH:15]=[CH:14][C:13]([S:16]([O:19]C)(=[O:18])=[O:17])=[CH:12][CH:11]=1.[CH3:22][C:23]([CH3:25])=[O:24]>>[C:10]1([CH3:21])[CH:11]=[CH:12][C:13]([S:16]([O-:19])(=[O:17])=[O:18])=[CH:14][CH:15]=1.[CH3:8][N+:1]12[CH2:6][CH2:5][CH:25]([CH2:3][CH2:2]1)[CH:23]([OH:24])[CH2:22]2

Participants

4

Reactant 3

HCID 180AcetoneHCID 6645Methyl p-toluenesulfonateHCID 14389216HCID 14389216, compound

Product 1

HCID 15052152HCID 15052152, compound

Procedure

In 10 ml of acetone was dissolved 1.27 g of quinuclidinol, and 1.86 g of methyl p-toluenesulfonate was added dropwise to the resulting solution. The mixture was stirred at room temperature, heated under reflux, and cooled to precipitate crystals. The crystals were collected by filtration and dried to give 2.81 g of the desired product.

Workup

  1. additionwas added dropwise to the resulting solution
  2. temperatureheated
  3. temperatureunder reflux
  4. temperaturecooled
  5. customto precipitate crystals
  6. filtrationThe crystals were collected by filtration
  7. customdried

Sources & evidence

ORD record
ord-682031b6504f4c84b51150fe467c7648
Source dataset
uspto-grants-1993_02
Patent number
US05183811

Reaction notes

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