4-Methyl-5-(2-hydroxyethyl)thiazole → HCID 15052263, compound

HRID 2081509Notes

Reaction equation

HRID 2081509 reaction equation
[OH:1][CH2:2][CH2:3][C:4]1[S:8][CH:7]=[N:6][C:5]=1[CH3:9].[C:10]1([CH3:21])[CH:15]=[CH:14][C:13]([S:16]([O:19]C)(=[O:18])=[O:17])=[CH:12][CH:11]=1>>[C:10]1([CH3:21])[CH:11]=[CH:12][C:13]([S:16]([O-:19])(=[O:17])=[O:18])=[CH:14][CH:15]=1.[CH3:10][N+:6]1[C:5]([CH3:9])=[C:4]([CH2:3][CH2:2][OH:1])[S:8][CH:7]=1

Participants

3

Reactant 2

HCID 11364-Methyl-5-(2-hydroxyethyl)thiazoleHCID 6645Methyl p-toluenesulfonate

Product 1

HCID 15052263HCID 15052263, compoundYield 148.8%

Procedure

The procedures of Reference Example 10 were repeated using 0.71 g of 5-(2-hydroxyethyl)-4-methylthiazole and 0.95 g of methyl p-toluenesulfonate to give 1.25 g of the desired compound.

Sources & evidence

ORD record
ord-0e642fa6c1894add85519ea0e1adddc9
Source dataset
uspto-grants-1993_02
Patent number
US05183811

Reaction notes

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