1-Methylpiperazine → HCID 18649758, compound

HRID 2081569Notes

Reaction equation

HRID 2081569 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:9]3=[C:10]([CH2:13][C@@H:14]([CH3:15])[N:8]3[CH:7]=[C:6]([C:16]([OH:18])=[O:17])[C:5]2=[O:19])[C:11]=1F.[CH3:20][N:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1>>[F:1][C:2]1[CH:3]=[C:4]2[C:9]3=[C:10]([CH2:13][C@@H:14]([CH3:15])[N:8]3[CH:7]=[C:6]([C:16]([OH:18])=[O:17])[C:5]2=[O:19])[C:11]=1[N:24]1[CH2:25][CH2:26][N:21]([CH3:20])[CH2:22][CH2:23]1

Participants

3

Reactant 2

HCID 531671-MethylpiperazineHCID 18649756HCID 18649756, compound2×

Product 1

HCID 18649758HCID 18649758, compound

Procedure

(-)-8,9-difluoro-2-(R)-methyl-6-oxo-1,2-dihydro-6H-pyrrolo[3,2,1-ij]quinoline-5-carboxylic acid (Compound (b)) and N-methylpiperazine were used, and treated in a manner analogous to Example 7, to give the title compound.

Workup

  1. additiontreated in a manner analogous to Example 7

Sources & evidence

ORD record
ord-18c502ea4ec64a87bdf96d07d24dd435
Source dataset
uspto-grants-1993_02
Patent number
US05185337

Reaction notes

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