反应详情

A mixture of the amine (Example 4) (0.25 g), 3-methylvaleric acid (0.07 g), 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (0.126 g) and 4-dimethylaminopyridine (0.02 g) in dichloromethane (5 ml) was stirred at room temperature for 96 hours. The reaction mixture was washed with water then saturated brine, dried over anhydrous magnesium sulphate, filtered and evaporated in vacuo. Purification by flash chromatography on silica, eluting with 0-30% ethyl acetate in hexane, afforded N-{1-[3-(3-methylbutylcarbonylamino)benzyl]indol-5-ylcarbonyl}-2-methylbenzene sulphonamide.

1. washThe reaction mixture was washed with water
2. dry with materialsaturated brine, dried over anhydrous magnesium sulphate
3. filtrationfiltered
4. customevaporated in vacuo
5. customPurification by flash chromatography on silica
6. washeluting with 0-30% ethyl acetate in hexane