反应详情

温度

45 °C

0.15 mol (25.05 g) of 2-amino-3-nitro-5-methylaniline is dissolved in 75 ml of pyridine, and 0.165 mol (31.4 g) of para-toluenesulphonyl chloride is then added gradually, whilst stirring, at between 40° and 45° C. When the addition has ended, the stirring is maintained for 1 hour at 45° C., the reaction medium is then poured into 450 ml of iced water and ther pyridine is neutralised with the aid of hydrochloric acid. The expected product which has precipitated is filtered off, washed with water and then recrystallised from acetic acid. After drying in vacuo, it melts at 184° C.

1. additionWhen the addition
2. customThe expected product which has precipitated
3. filtrationis filtered off
4. washwashed with water
5. customrecrystallised from acetic acid
6. customAfter drying in vacuo, it melts at 184° C.