Diethyl Ether → 142348-17-2

HRID 2082130Notes

Reaction equation

HRID 2082130 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[N:7]1[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1.[Br:13][CH2:14][CH2:15][CH2:16][CH2:17]Br.C(=O)([O-])[O-].[Na+].[Na+].CCOCC>C(O)(C)C>[Br-:13].[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[N:7]1[CH2:8][CH2:9][N+:10]2([CH2:17][CH2:16][CH2:15][CH2:14]2)[CH2:11][CH2:12]1

Participants

6

Reactant 4

HCID 3283Diethyl EtherHCID 80561,4-DibromobutaneHCID 10340Sodium CarbonateHCID 944591-(2-Pyridyl)piperazine

Product 1

HCID 658423142348-17-2

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

A mixture of 40.8 g (0.25 mol) of 1-(2-pyridyl) piperazine (IV), 75.5 ml (134.9 g, 0.625 mol) of 1,4-dibromobutane (V) and 27.5 g (0.26 mol) of sodium carbonate was refluxed in 500 g of isopropyl alcohol for 16 hours, the hot mixture was filtered off from the salt precipitate, cooled, and the crystalline product was isolated. The additional amount of the product can be obtained by dilution of the mother liquor with a double volume of ether.

Workup

  1. filtrationthe hot mixture was filtered off from the salt precipitate
  2. temperaturecooled
  3. customthe crystalline product was isolated

Sources & evidence

ORD record
ord-40188b3f3f644e2abd31b062beccdd31
Source dataset
uspto-grants-1993_02
Patent number
US05187277

Reaction notes

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