Potassium Carbonate → HCID 13365961, compound

HRID 2082138Notes

Reaction equation

HRID 2082138 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]2[S:9](=[O:11])(=[O:10])[N:8]([CH2:12][CH2:13][CH2:14][CH2:15]Br)[C:7](=[O:17])[C:6]=2[CH:18]=1.[N:19]1[CH:24]=[CH:23][CH:22]=[N:21][C:20]=1[N:25]1[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]1.C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[N:19]1[CH:24]=[CH:23][CH:22]=[N:21][C:20]=1[N:25]1[CH2:30][CH2:29][N:28]([CH2:15][CH2:14][CH2:13][CH2:12][N:8]2[C:7](=[O:17])[C:6]3[CH:18]=[C:2]([F:1])[CH:3]=[CH:4][C:5]=3[S:9]2(=[O:11])=[O:10])[CH2:27][CH2:26]1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 887471-(2-Pyrimidinyl)piperazineHCID 13365982HCID 13365982, compound

Product 1

HCID 13365961HCID 13365961, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

0.02 mol of 5-fluoro-2-(4-bromobutyl)-1,2-benzisothiazol-3(2H)one 1,1-dioxide and 0.02 mol of 1-(2-pyrimidinyl)piperazine are stirred with 0.02 mol of K2CO3 in 150 ml of absolute DMF at 100° C. for 1 hour. The mixture is then evaporated. Water is added and the organic substance is taken up in methylene chloride. The dried CH2Cl2 phase is applied to a silica gel column and eluted with CH2Cl2 /CH3OH (95:5).

Workup

  1. customThe mixture is then evaporated
  2. additionWater is added
  3. washeluted with CH2Cl2 /CH3OH (95:5)

Sources & evidence

ORD record
ord-9bf2a57e568f4ed682edc27c05203bb7
Source dataset
uspto-grants-1993_02
Patent number
US05187276

Reaction notes

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