Piperazine → 5-Iodo-2-(piperazin-1-yl)pyrimidine

HRID 2082142Notes

Reaction equation

HRID 2082142 reaction equation
Cl[C:2]1[N:7]=[CH:6][C:5]([I:8])=[CH:4][N:3]=1.[NH:9]1[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]1>CN(C)C=O>[I:8][C:5]1[CH:4]=[N:3][C:2]([N:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)=[N:7][CH:6]=1

Participants

4

Reactant 2

HCID 4837PiperazineHCID 17142232-Chloro-5-iodopyrimidine

Product 1

HCID 157298765-Iodo-2-(piperazin-1-yl)pyrimidine

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

0.02 mol of 2-chloro-5-iodopyrimidine, 0.06 mol of piperazine and 100 ml of absolute dimethylformamide are heated to 100° for 45 minutes and then evaporated. The crystalline residue is shaken with potassium bicarbonate solution and methylene chloride. The substance contained in the methylene chloride phase is purified by column chromatography over silica gel 60. The amine obtained by elution with methylene chloride/methanol (7:3) is stirred with isopropyl ether and filtered off with suction.

Workup

  1. customevaporated
  2. customis purified by column chromatography over silica gel 60

Sources & evidence

ORD record
ord-5f1ca74c94964d0d97b18d5811328ea6
Source dataset
uspto-grants-1993_02
Patent number
US05187276

Reaction notes

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