反应详情

温度

60 °C

0.01 mol of 2-(3-bromopropyl)-7-methoxy-1,2,4-benzothiadiazin-3(4H)one 1,1-dioxide, 0.012 mol of 1-(2-pyrimidinyl)piperazine and 0.01 mol of triethylamine are dissolved in 30 ml of DMF and the solution is heated at 60° C., with stirring, for 1.5 hours. Then 15 ml of water are added and the reaction mixture is cooled to 0° C. The substance which crystallises out during this is filtered off with suction, stirred with isopropanol, again filtered off with suction and dried in vacuo. Yield: 53% of theory; melting point: 178° C.

1. temperaturethe reaction mixture is cooled to 0° C
2. customThe substance which crystallises out during
3. filtrationthis is filtered off with suction
4. stirringstirred with isopropanol
5. filtrationagain filtered off with suction
6. customdried in vacuo