Dimethylformamide → N-(5-(4-acetylpiperazin-1-yl)pyridin-2-yl)-2-(3-cyano-4-(2-fluoropyridin-4-yl)phenyl)acetamide

HRID 208216Notes

Reaction equation

HRID 208216 reaction equation
[C:1](#[N:2])[c:3]1[cH:4][c:5]([CH2:16][C:17](=[O:18])[OH:19])[cH:6][cH:7][c:8]1-[c:9]1[cH:10][c:11]([F:15])[n:12][cH:13][cH:14]1.[CH:36]([N:37]([CH2:38][CH3:39])[CH:40]([CH3:41])[CH3:42])([CH3:43])[CH3:44].[NH2:20][c:21]1[cH:22][cH:23][c:24]([N:27]2[CH2:28][CH2:29][N:30]([C:33]([CH3:34])=[O:35])[CH2:31][CH2:32]2)[cH:25][n:26]1.[O:69]=[CH:70][N:71]([CH3:72])[CH3:73].[P-:45]([F:46])([F:47])([F:48])([F:49])([F:50])[F:51].[n:52]1([O:53][C:54]([N:55]([CH3:56])[CH3:57])=[N+:58]([CH3:59])[CH3:60])[c:61]2[n:62][cH:63][cH:64][cH:65][c:66]2[n:67][n:68]1>>[C:1](#[N:2])[c:3]1[cH:4][c:5]([CH2:16][C:17](=[O:19])[NH:20][c:21]2[cH:22][cH:23][c:24]([N:27]3[CH2:28][CH2:29][N:30]([C:33]([CH3:34])=[O:35])[CH2:31][CH2:32]3)[cH:25][n:26]2)[cH:6][cH:7][c:8]1-[c:9]1[cH:10][c:11]([F:15])[n:12][cH:13][cH:14]1

Participants

7

Reactant 6

HCID 6228DimethylformamideHCID 9886HexafluorophosphateHCID 81531DiisopropylethylamineHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 284116891-(4-(6-Aminopyridin-3-YL)piperazin-1-YL)ethan-1-oneHCID 68247400HCID 68247400, compound

Product 1

HCID 58447806N-(5-(4-acetylpiperazin-1-yl)pyridin-2-yl)-2-(3-cyano-4-(2-fluoropyridin-4-yl)phenyl)acetamide

Sources & evidence

ORD record
ord-44d53107fde040fabcd027033a228b2f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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