反应详情

温度

-20 °C

A solution of 4.2 g of cis-(1RS)-1-formyl-(6RS)-6-[(1E,3E)-(5RS)-5-acetoxy-1,3-tridecadienyl]-3-cyclohexene in 8.25 ml of tetrahydrofuran is installed in 29.9 ml of this magnesium organic solution at -20° C. under argon and stirred for 30 minutes at -20° C. It is mixed with 150 ml of saturated ammonium chloride solution, extracted three times with ether, the organic phase is shaken out with brine, dried on magnesium sulfate and concentrated by evaporation in a vacuum. The residue is chromatographed on silica gel. With hexane/ethyl acetate (8+2), 4.1 g of the alcohol is obtained as a colorless oil.

1. extractionextracted three times with ether
2. stirringthe organic phase is shaken out with brine
3. customdried on magnesium sulfate
4. concentrationconcentrated by evaporation in a vacuum
5. customThe residue is chromatographed on silica gel