Hydrochloric Acid → HCID 67857936, compound

HRID 2082342Notes

Reaction equation

HRID 2082342 reaction equation
[C:1]1([CH2:7][O:8][C:9](=[O:37])[CH2:10][CH:11]([NH2:36])[C:12](=[O:35])[NH:13][CH2:14][CH:15]2[CH2:20][CH2:19][CH2:18][CH2:17][N:16]2[C:21](=[O:34])[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH3:33])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:38]>C(OCC)C>[ClH:38].[C:1]1([CH2:7][O:8][C:9](=[O:37])[CH2:10][CH:11]([NH2:36])[C:12](=[O:35])[NH:13][CH2:14][CH:15]2[CH2:20][CH2:19][CH2:18][CH2:17][N:16]2[C:21](=[O:34])[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH3:33])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 53795759HCID 53795759, compound

Product 1

HCID 67857936HCID 67857936, compoundYield 87%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

To a rapidly stirred solution of 400 mg (0.77 mmol) of 3-amino-4-oxo-4-[([1-(1-oxotridecyl)-2-piperidinyl]methyl)amino]butanoic acid phenylmethyl ester in 6.0 mL of diethyl ether was added 1.5 mL (1.5 mmol) of 1.0N HCl in diethyl ether. The mixture was stirred for 3 minutes and then the resulting solid was collected by vacuum filtration, providing 370 mg (87%) of 3-amino-4-oxo-4-[([1-(1-oxotridecyl)-2-piperidinyl]methyl)amino]butanoic acid phenylmethyl ester hydrochloride as a yellow solid. Mp.>55° C. (decomposition).

Workup

  1. filtrationthe resulting solid was collected by vacuum filtration

Sources & evidence

ORD record
ord-c0a6992c4d30464daaf92173726e44ce
Source dataset
uspto-grants-1993_02
Patent number
US05189046

Reaction notes

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