Ethyl Acrylate → N-[1-(ethoxycarbonylethyl)-piperid-4-yl]-N-methylpropionamide

HRID 2082346Notes

Reaction equation

HRID 2082346 reaction equation
[C:1]([O:5][CH2:6][CH3:7])(=[O:4])[CH:2]=[CH2:3].[NH:8]1[CH2:13][CH2:12][CH:11]([N:14]([CH3:19])[C:15](=[O:18])[CH2:16][CH3:17])[CH2:10][CH2:9]1>C(O)C>[CH2:6]([O:5][C:1]([CH2:2][CH2:3][N:8]1[CH2:13][CH2:12][CH:11]([N:14]([CH3:19])[C:15](=[O:18])[CH2:16][CH3:17])[CH2:10][CH2:9]1)=[O:4])[CH3:7]

Participants

4

Reactant 2

HCID 8821Ethyl AcrylateHCID 19761222N-Methyl-N-(piperidin-4-yl)propionamide

Product 1

HCID 19761283N-[1-(ethoxycarbonylethyl)-piperid-4-yl]-N-methylpropionamide

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

14 g of ethyl acrylate in 45 ml of ethanol are added dropwise to 23.8 g of the amine obtained in Stage C of Example 1 dissolved in 45 ml of ethanol. The mixture is stirred at room temperature for 3 hours, evaporated, and the residual oil is distilled in a Kugelrohr (bulb tube) at 120° C. and 0.09 mg Hg.

Workup

  1. customevaporated
  2. distillationthe residual oil is distilled in a Kugelrohr (bulb tube) at 120° C.

Sources & evidence

ORD record
ord-b70e6d78ea6046bbb08cd017da67c6e3
Source dataset
uspto-grants-1993_02
Patent number
US05189045

Reaction notes

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