Methylamine → 1-[4-(Methylamino)piperidin-1-yl]ethan-1-one

HRID 2082351Notes

Reaction equation

HRID 2082351 reaction equation
[CH3:1][NH2:2].[C:3]([N:6]1[CH2:11][CH2:10][C:9](=O)[CH2:8][CH2:7]1)(=[O:5])[CH3:4]>C(O)C.[Pt]=O>[C:3]([N:6]1[CH2:11][CH2:10][CH:9]([NH:2][CH3:1])[CH2:8][CH2:7]1)(=[O:5])[CH3:4]

Participants

5

Reactant 2

HCID 6329MethylamineHCID 122563N-Acetyl-4-piperidone

Product 1

HCID 197612651-[4-(Methylamino)piperidin-1-yl]ethan-1-one

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 702EthanolSolvent2×

Procedure

9.9 g of methylamine in 50 ml of ethanol are added to 14.4 g of 1-acetyl-4-oxopiperidine in 100 ml of ethanol. The mixture is then hydrogenated in the presence of platinum oxide at room temperature and atmospheric pressure, filtered and evaporated.

Workup

  1. filtrationatmospheric pressure, filtered
  2. customevaporated

Sources & evidence

ORD record
ord-d403338957fe41e2b26a0fbe34918afc
Source dataset
uspto-grants-1993_02
Patent number
US05189045

Reaction notes

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