Ethyl Acrylate → N-[1-(ethoxycarbonylethyl)-piperid-4-yl]-N-methylpropionamide

HRID 2082358Notes

Reaction equation

HRID 2082358 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([N:7]([CH3:12])[C:8](=[O:11])[CH2:9][CH3:10])[CH2:3][CH2:2]1.[C:13]([O:17][CH2:18][CH3:19])(=[O:16])[CH:14]=[CH2:15]>C(O)C>[CH2:18]([O:17][C:13]([CH2:14][CH2:15][N:1]1[CH2:6][CH2:5][CH:4]([N:7]([CH3:12])[C:8](=[O:11])[CH2:9][CH3:10])[CH2:3][CH2:2]1)=[O:16])[CH3:19]

Participants

4

Reactant 2

HCID 8821Ethyl AcrylateHCID 19761222N-Methyl-N-(piperidin-4-yl)propionamide

Product 1

HCID 19761283N-[1-(ethoxycarbonylethyl)-piperid-4-yl]-N-methylpropionamide

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

7.4 g of the compound obtained in Stage C of Example 1 are dissolved in 10 ml of ethanol, then 4.73 ml of ethyl acrylate dissolved in 12 ml of ethanol are poured onto the solution. The mixture is left at room temperature for one night, and then concentrated in a rotary evaporator and distilled in a Kugelrohr to yield the compound in the form of an oil.

Workup

  1. additionare poured onto the solution
  2. waitThe mixture is left at room temperature for one night
  3. concentrationconcentrated in a rotary evaporator
  4. distillationdistilled in a Kugelrohr
  5. customto yield the compound in the form of an oil

Sources & evidence

ORD record
ord-a719ef78986d43f6a1540eae9e37334b
Source dataset
uspto-grants-1993_02
Patent number
US05189045

Reaction notes

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