反应详情

21 g of 1-tert-butoxycarbonyl-indoline-2-carboxylic acid, then 35.2 g of 1-benzotriazolyl-oxytris (dimethylamino)phosphonium hexafluorophosphate (BOP) and the 24.2 g of triethylamine are added successively to a solution of 23.5 g of 2-amino-4-(2,4,6-trimethylphenyl)thiazole hydrobromide in 250 ml of dimethylformamide. The reaction mixture is stirred at ambient temperature for 12 h. The solvent is then evaporated under reduced pressure and 150 ml of ethyl acetate are poured onto the residue. The organic solution is washed with a saturated aqueous NaCl solution and dried over anhydrous magnesium sulphate. The solid obtained after evaporation of the solvent is washed with diisopropyl ether. Yield: 95%.

1. customThe solvent is then evaporated under reduced pressure and 150 ml of ethyl acetate
2. additionare poured onto the residue
3. washThe organic solution is washed with a saturated aqueous NaCl solution
4. dry with materialdried over anhydrous magnesium sulphate
5. customThe solid obtained
6. customafter evaporation of the solvent
7. washis washed with diisopropyl ether