反应详情

A mixture of 5-chlorosalicylamide (16.0 g., 0.093 mole), iodoethane (31.8 g., 0.204 mole), and potassium carbonate (13.1 g., 0.095 mole) in ethanol (225 ml.) was heated under reflux for 20 hours. The hot mixture was filtered. The filtrate was reduced to dryness. The residue was triturated with water. The mixture was filtered and the collected solid recrystallized from acetonitrile to give 5-chloro-2-ethoxybenzamide (6.8 g., 36.6%) m.p. 136°-139°.

1. temperaturewas heated
2. temperatureunder reflux for 20 hours
3. filtrationThe hot mixture was filtered
4. customThe residue was triturated with water
5. filtrationThe mixture was filtered
6. customthe collected solid recrystallized from acetonitrile