Acetic Acid → HCID 85907800, compound

HRID 2083021Notes

Reaction equation

HRID 2083021 reaction equation
[O:1]=[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([C:12](OC)=[O:13])[CH:10]=2)[N:5]=[C:4]2[CH:16]=[CH:17][CH:18]=[CH:19][N:3]12.Cl.[NH2:21][OH:22].C(NC(C)C)(C)C.C(O)(=O)C>CN(C)C=O>[O:1]=[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([C:12]([NH:21][OH:22])=[O:13])[CH:10]=2)[N:5]=[C:4]2[CH:16]=[CH:17][CH:18]=[CH:19][N:3]12

Participants

6

Reactant 4

HCID 176Acetic AcidHCID 7912DiisopropylamineHCID 443297Hydroxyamine hydrochlorideHCID 131711072HCID 131711072, compound

Product 1

HCID 85907800HCID 85907800, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
20 °C

Procedure

5.9 gm of 11-oxo-11-H-pyrido[2,1-b]quinazoline-2-carboxylic acid chloride (see Example 12) were introduced into a solution of 2.08 gm of hydroxylamine hydrochloride and 9.8 ml of diisopropylamine in 100 ml of dimethylformamide, and the mixture was stirred at 20° C for 5 hours. Thereafter, the reaction mixture was acidified with dilute acetic acid and suction-filtered, yielding as the filter cake the semihyrate of the formula ##STR25##

Workup

  1. filtrationsuction-filtered
  2. customyielding as the filter cake the semihyrate of the formula

Sources & evidence

ORD record
ord-fcbc24e94e504bf6a89510b38f73b479
Source dataset
uspto-grants-1978_04
Patent number
US04083980

Reaction notes

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