Hydrochloric Acid → HCID 85907803, compound

HRID 2083022Notes

Reaction equation

HRID 2083022 reaction equation
[O:1]=[C:2]1[C:11]2[CH:10]=[C:9]([C:12]([O:14]CC)=[O:13])[CH:8]=[CH:7][C:6]=2[N:5]=[C:4]2[CH:17]=[CH:18][C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][C:24]=3[N:3]12.[OH-].[Na+].Cl>O>[O:1]=[C:2]1[C:11]2[CH:10]=[C:9]([C:12]([OH:14])=[O:13])[CH:8]=[CH:7][C:6]=2[N:5]=[C:4]2[CH:17]=[CH:18][C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][C:24]=3[N:3]12

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 85907754HCID 85907754, compound

Product 1

HCID 85907803HCID 85907803, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

2.8 gm of ethyl 12-oxo-12-H-quino[2,1-b]quinazoline-10-carboxylate (see Example 3) were refluxed in 20 ml of an aqueous 10% sodium hydroxide solution for 30 minutes. The solution was then heated with 5 times its quantity of semiconcentrated hydrochloric acid for half an hour on a boiling water bath. After diluting with water, the precipitated yellow crystals were collected by suction filtration and washed with water and acetonitrile, yielding the compound of the formula ##STR26##

Workup

  1. filtrationthe precipitated yellow crystals were collected by suction filtration
  2. washwashed with water and acetonitrile
  3. customyielding the compound of the formula

Sources & evidence

ORD record
ord-beff7297bf76462597040414b05698c8
Source dataset
uspto-grants-1978_04
Patent number
US04083980

Reaction notes

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