1,4-Dibromobutane → HCID 53670576, compound

HRID 2083108Notes

Reaction equation

HRID 2083108 reaction equation
[CH2:1]([O:3][C:4](=[O:13])[CH:5]([CH3:12])[O:6][CH2:7][CH2:8][CH2:9][CH2:10]I)[CH3:2].[Br:14]CCCCBr.[H-].[Na+]>C1COCC1>[CH2:1]([O:3][C:4](=[O:13])[CH:5]([CH3:12])[O:6][CH2:7][CH2:8][CH2:9][CH2:10][Br:14])[CH3:2]

Participants

5

Reactant 3

HCID 80561,4-DibromobutaneHCID 24758Sodium hydrideHCID 53967419HCID 53967419, compound

Product 1

HCID 53670576HCID 53670576, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The lactic acid ethyl ester and 1,4-dibromo-butane were reacted in THF in the presence of NaH to obtain 7-bromo-2-methyl-3-oxaheptanoic acid ethyl ester and subsequently, the exchange of bromine and iodine was carried out, as described in 4 (d). Boiling point2.3 : 120° - 123° C.

Sources & evidence

ORD record
ord-82f32fc6cec54fc7b6f0554583b9b069
Source dataset
uspto-grants-1978_04
Patent number
US04083990

Reaction notes

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