Hydrochloric Acid → HCID 20358234, compound

HRID 2083218Notes

Reaction equation

HRID 2083218 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][C:11]([CH:13]([OH:19])[CH2:14][CH2:15][C:16]([OH:18])=O)=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.Cl>C(OCC)(=O)C.CCCCCC>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[O:12][C:11]([CH:13]3[O:19][C:16](=[O:18])[CH2:15][CH2:14]3)=[CH:10][CH:9]=2)=[CH:6][CH:7]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 20358229HCID 20358229, compound

Product 1

HCID 20358234HCID 20358234, compound

Reagents, catalysts & solvents 2

HCID 8058HexaneSolventHCID 8857Ethyl AcetateSolvent

Procedure

A mixture of 3.8 g (0.014 mole) of 4-[5-(4-fluorophenyl)-2-furanyl]-4-hydroxybutanoic acid and 60 ml of 10% hydrochloric acid was warmed at 45° for 2 hrs and then cooled in an ice bath. The solid was filtered, washed with water and air-dried to yield 3.3 g (95%). An analytical sample was prepared by dissolving a sample in ethyl acetate (Darco), diluting with hexane and drying the resulting solid in a vacuum pistol at room temperature, m.p. 57°-59°.

Workup

  1. temperaturewas warmed at 45° for 2 hrs
  2. temperaturecooled in an ice bath
  3. filtrationThe solid was filtered
  4. washwashed with water
  5. customair-dried
  6. customto yield 3.3 g (95%)
  7. customAn analytical sample was prepared
  8. customdrying the resulting solid in a vacuum pistol at room temperature

Sources & evidence

ORD record
ord-dc14e44ce5f448828d8ade32448e4677
Source dataset
uspto-grants-1978_04
Patent number
US04085118

Reaction notes

Loading…