反应详情

3,3-bis(Hydroxymethyl)butanone (39.6 g), benzene (200 ml), anisaldehyde (40.8) and toluene-p-sulphonic acid (200 mg) were heated under reflux in a Dean and Stark water trap until the theoretical amount of water had separated. The solution was concentrated in vacuo and the solid residue was crystallised from isopropyl acetate as a white crystalline solid m.p. 112°-114°, cis isomer.

1. customhad separated
2. concentrationThe solution was concentrated in vacuo
3. customthe solid residue was crystallised from isopropyl acetate as a white crystalline solid m.p. 112°-114°, cis isomer